Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC MYK-461 1642288-47-8 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A87205.1
MYK-461 is a small-molecule inhibitor interacting directly with cardiac myosin heavy chain to modulate myocardial contraction It specifically reduces myocardial contractility through inhibition of cardiac myosin ATPase enzymatic activity thereby limiting myosin-mediated phosphate release without affecting ADP dissociation rates In rodent cardiomyocytes MYK-461 demonstrates dose-dependent reductions in fractional shortening and sarcomeric force generation without impacting calcium transient dynamics Its inhibitory potency against cardiac myosin ATPase surpasses that observed for skeletal muscle isoforms In preclinical hypertrophic cardiomyopathy mouse models MYK-461 administration attenuates cardiac contractile function facilitating investigations into myocardial contractility regulation and potential therapeutic strategies against hypertrophic cardiomyopathy
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?