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Medchemexpress LLC N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide | 365462-23-3 | 98.05% | 474.55 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY14853100MG

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Darexaban (YM150) is described as a potent, selective, and orally active factor Xa (FXa) inhibitor with an IC50 of 54.6 nM. It exhibits high selectivity against other related serine proteases, such as trypsin, thrombin, and kallikrein, and has demonstrated anticoagulant and antithrombotic effects.

  • Potent and selective FXa inhibitor (IC50 of 54.6 nM) preventing blood clot formation.
  • Orally active for convenient administration.
  • Exhibits anticoagulant and antithrombotic effects.
  • High selectivity, primarily inhibiting FXa without affecting other related serine proteases.
  • Rapidly metabolized into its glucuronide conjugate (YM-222714).
  • In vivo efficacy: inhibits FXa activity in mice (ED50 24.8 mg/kg), prolongs PT, reduces mortality in PE mouse model, and decreases thrombus protein in VT mouse model.

Catalog No. 50-003-61566


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