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Medchemexpress LLC N-(3-(4-(((2-aminoethyl)(methyl)amino)methyl)-1H-pyrrol-3-yl)-phenyl)acrylamide | 2702280-86-0 | 98.0% | C17H22N4O | 10MG
SDP

Supplier:  Medchemexpress LLC HY13374010MG

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MS117 is a first-in-class, cell-active irreversible covalent inhibitor of protein arginine methyltransferase 6 (PRMT6). It inhibits PRMT6 with high biochemical potency and engages the enzyme covalently via an acrylamide Michael acceptor that modifies Cys50, showing both time-dependent irreversible inhibition and cellular activity.

  • Irreversible covalent mechanism targeting Cys50.
  • Potent biochemical inhibition of PRMT6 (IC50 ≈ 18 nM).
  • Demonstrated cellular activity in histone methylation assays.
  • Selective profile versus many other methyltransferases at relevant concentrations.
  • Available as solid and as DMSO solution to support assay workflows.

Catalog No. 50-002-58313


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