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Medchemexpress LLC N-[3-[5-[(1-ethyl-4-piperidinyl)methylamino]-3-(5-pyrimidinyl)-1H-pyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]-1-propanesulf... | 1392429-79-6 | 99.2% | 569.67 g·mol⁻¹ | C28H33F2N7O2S | 100 MG
SDP

Catalog No. 5000241545
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BI-882370 is a potent, selective pan-RAF kinase inhibitor used in preclinical research to probe RAF/MEK/ERK signaling and to evaluate antitumor activity in BRAF-mutant and wild-type models. It binds the ATP site in the DFG-out (inactive) conformation and exhibits sub-nanomolar to low-nanomolar inhibition of BRAF V600E, wild-type BRAF, and CRAF, making it useful as a research tool for pathway modulation and efficacy studies.

  • Potent RAF kinase inhibition with sub-nanomolar to low-nanomolar activity.
  • Binds the ATP site in the DFG-out (inactive) conformation.
  • Suitable for in vitro and in vivo preclinical studies.
  • Supplied in solid and DMSO solution formats for assay flexibility.
  • High reported purity appropriate for research applications.

Catalog No. 50-002-41545 Supplier Medchemexpress LLC Supplier No. HY107779100MG
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BI-882370 is a potent, selective pan-RAF kinase inhibitor used in preclinical research to probe RAF/MEK/ERK signaling and to evaluate antitumor activity in BRAF-mutant and wild-type models. It binds the ATP site in the DFG-out (inactive) conformation and exhibits sub-nanomolar to low-nanomolar inhibition of BRAF V600E, wild-type BRAF, and CRAF, making it useful as a research tool for pathway modulation and efficacy studies.

  • Potent RAF kinase inhibition with sub-nanomolar to low-nanomolar activity.
  • Binds the ATP site in the DFG-out (inactive) conformation.
  • Suitable for in vitro and in vivo preclinical studies.
  • Supplied in solid and DMSO solution formats for assay flexibility.
  • High reported purity appropriate for research applications.

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