Medchemexpress LLC N'-[3-[[5-bromo-2-[3-(pyrrolidine-1-carbonylamino)anilino]pyrimidin-4-yl]amino]propyl]-2,2-dimethylpropanediamide | 702676-93-5 | MFCD12922516 | 99.4% | 547.45 g·mol⁻1 | C23H31BrN8O3 | 1 MG

Supplier:  Medchemexpress LLC HY105151MG

BX-320 is a selective, ATP-competitive, orally active small-molecule inhibitor of PDK1 for preclinical research. It inhibits PDK1 with an IC50 of 30 nM, blocks PDK1/Akt signaling, induces apoptosis in tumor cells, and has demonstrated antiproliferative and antitumor activity in cell-based and animal models.

• Selective ATP-competitive PDK1 inhibitor (IC50 30 nM).
• Blocks PDK1/Akt signaling and induces apoptosis in tumor cells.
• Demonstrates antiproliferative activity in cell assays and efficacy in in vivo tumor models.
• Exhibits off-target activity against Chk1, c-Kit, KDR, PKA, CDK2, GSK3β, and PKC at micromolar concentrations.
• High purity (99.4%).
• Molecular weight 547.45 g·mol⁻1; formula C23H31BrN8O3.
• Store solid at -20°C; in solvent store at -80°C (up to 6 months) or -20°C (up to 1 month).

Catalog No. 50-002-43934