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Cayman Chemical N 3PhenylpropIonylglycIn 100mg
Supplier: Cayman Chemical 34392100 MG
A dual VEGFR and PDGFR family kinase inhibitor (IC50s 0.002 0.05 0.004 and 0.015 UM for VEGFR1 VEGFR2 PDGFRB and KIT respectively) selective for these kinases over FGFR1 EGFR Src and c-Met (IC50s 3.5 20 2.5 and 9 UM respectively) inhibits VEGFR2 PDGFRB KIT and FLT3-ITD phosphorylation in vitro (IC50s 0.04 0.02 0.006 and 0.05 UM respectively) inhibits PDGF-dependent proliferation of NIH3T3 cells overexpressing PDGFRB as well as OC1-AML5 cells expressing wild-type FLT3 and MV4-11 cells carrying the activating FLT3-ITD mutation inhibits VEGF-induced survival of HUVECs (IC50 6.8 nM) reduces tumor growth in human acute myeloid leukemia renal and colon cancer as well as rat glioma mouse xenograft models when used at doses ranging from 10-80 mg/kg twice per day
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