Medchemexpress LLC N-[4-(2-chloro-5-methylpyrimidin-4-yl)phenyl]-N-[(4-(difluoroacetylamino)methyl)phenyl]methyl-2,4-dihydroxybenzamide | 1684386-71-7 | 99.1% | 552.96 g/mol | C28H23ClF2N4O4 | 25MG

Supplier:  Medchemexpress LLC HY1249225MG

VER-246608 is a potent, ATP-competitive inhibitor of pyruvate dehydrogenase kinase (PDK) isoforms, developed for biochemical and cell-based research. It shows sub-100 nM enzymatic potency across PDK isoforms and reduces E1α Ser293 phosphorylation in cellular assays. Supplied as a solid and as DMSO solutions for laboratory use.

• Potent ATP-competitive inhibition of pyruvate dehydrogenase kinase isoforms.
• IC50 values: PDK-1 35 nM; PDK-3 40 nM; PDK-2 84 nM; PDK-4 91 nM.
• Suppresses phosphorylation of E1α Ser293 in cellular assays (IC50 ≈ 266 nM).
• High purity: 99.1%.
• Molecular formula C28H23ClF2N4O4; molecular weight 552.96 g/mol.
• Available as solid (25 MG) and as 10 mM solutions in DMSO for convenience.
• Recommended storage: powder at -20°C or 4°C; in solvent store at -80°C for long-term stability.

Catalog No. 50-002-35093