Sigma Aldrich N-(4-Bromophenyl)-N-Phenylacrylamide

Catalog No.	Quantity
91-179-8100MG	100 mg

Catalog No. 91-179-8100MG Supplier Sigma Aldrich Supplier No. 911798100MG

Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

N-(4-Bromophenyl)-N-phenylacrylamide is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as undruggable, or difficult-to-target, proteins. This fragment electrophile, or scout fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC™ molecules for targeted protein degradation as demonstrated by the Cravatt Lab for E3 ligase discovery.Technology Spotlight: Proteomic Ligandability AssessmentProteome-wide covalent ligand discovery in native biological systemsElectrophilic PROTACs that degrade nuclear proteins by engaging DCAF16PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

• CAS: 29463-06-7
• Molecular Formula: C16H23BBrNO4
• Quantity: 100 mg
• Synonym: Benzyl boronate tag; Bromoethyl boronic acid pinacol ester nuclear tag; Nucleus-targeting probe building block
• Molecular Weight (g/mol): 384.07 g/mol