Medchemexpress LLC N-(4-ethoxyphenyl)-2-[[2-methyl-5-(methylsulfonyl)-1-benzimidazolyl]methyl]anilinecarbothioamide | 484006-66-8 | 98.2% | 425.54 | C23H27N3O3S | 10 MG

Supplier:  Medchemexpress LLC HY10308110MG

β-Glucuronidase-IN-1 is a potent, selective, uncompetitive inhibitor of E. coli β-glucuronidase with demonstrated cellular and in vivo activity. It inhibits the enzyme with IC50 = 283 nM and Ki = 164 nM, shows cellular EC50 = 17.7 nM, and protects mouse GI epithelium from CPT-11-induced damage when dosed orally.

• Potent, selective uncompetitive inhibitor of E. coli β-glucuronidase.
• Biochemical potency: IC50 283 nM; Ki 164 nM.
• Cellular activity: EC50 17.7 nM in bacterial cells.
• Oral efficacy demonstrated in mouse CPT-11 toxicity model.
• Available as solid mg quantities and as 10 mM solution in DMSO for assays.
• High purity and characterized by formula C23H27N3O3S and molecular weight 425.54.

Catalog No. 50-002-47433