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Medchemexpress LLC N-(4-mesitylthiazol-2-yl)benzamide | 1001753-24-7 | 99.5% | 322.42 | C19H18N2OS | 25 MG
SDP

Supplier:  Medchemexpress LLC HY10054125MG

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INH6 is a small-molecule Nek2/Hec1 inhibitor that inactivates Hec1/Nek2 function via protein degradation, leading to chromosome missegregation and cell death. It inhibits HeLa cell growth with an IC50 of 2.4 μM and produces mitotic defects and apoptosis in treated cells.

  • Potent Nek2/Hec1 inhibition (IC50 2.4 μM).
  • Inactivates Hec1/Nek2 through protein degradation, causing chromosome missegregation.
  • Induces mitotic defects and apoptosis in cultured cells (~20% apoptotic cells at 72 h).
  • Solid, white to off-white powder; soluble in DMSO (50 mg/mL) and in 10% DMSO/90% corn oil for animal dosing.
  • Stable as powder at -20°C (3 years) and 4°C (2 years); in solvent stability varies by temperature.

Catalog No. 50-002-14943


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