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Medchemexpress LLC N-(Azido-PEG2)-N-bis(PEG4-Boc) | 2112731-81-2 | C36H70N4O14 | 250 MG
Supplier: Medchemexpress LLC 250MGHY140867
N-(Azido-PEG2)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that functions as a click chemistry reagent. It contains an Azide group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This linker is used in the synthesis of PROTACs, which leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Used in the synthesis of PROTACs.
- Functions as a click chemistry reagent.
- Contains an Azide group, enabling CuAAc reactions with Alkyne groups and SPAAC reactions with DBCO or BCN groups.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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