Medchemexpress LLC N-DBCO-N-bis(PEG2-C2-NHS ester) | 2128735-29-3 | 95.0% | C41H46N4O14 | 100 MG

Supplier:  Medchemexpress LLC HY140585100MG

N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It functions as a click chemistry reagent, featuring a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. PROTACs utilize two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other targets a protein of interest, leveraging the intracellular ubiquitin-proteasome system for selective protein degradation. This product is intended for research use only.

Features and benefits:

• PEG-based PROTAC linker
• Facilitates click chemistry via DBCO group
• Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
• Supports selective degradation of target proteins
• Solid appearance, light yellow to brown in color
• Powder storage at -20°C for 3 years
• In solvent storage at -80°C for 6 months or -20°C for 1 month

Catalog No. 50-003-56666