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Cayman Chemical N-Desbutyl Drondaronhydro 10mg
SDP

Supplier:  Cayman Chemical 3488810 MG

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An active metabolite of dronedarone; inhibits T3 binding to TRα1 and TRβ1 (IC50s = 59 and 280 µM for the chicken and human receptors, respectively); inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide hydrolase-mediated formation of 14,15-DHET from 14,15-EET (IC50s = 1.59 and 2.73 µM, respectively, in cell-free assays); decreases intracellular ATP levels in H9c2 rat cardiomyocytes (IC50 = 1.07 µM); inhibits mitochondrial complex I and mitochondrial complex II activities in isolated rat heart mitochondria (IC50s = 11.94 and 24.54 µM, respectively)

Catalog No. 50-291-1033


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