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Medchemexpress LLC N-desmethyltamoxifen hydrochloride | 15917-65-4 | 99.6% | 50 MG
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Supplier:  Medchemexpress LLC HY129099A50MG

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N-Desmethyltamoxifen hydrochloride is the principal metabolite of tamoxifen found in humans. It acts as a poor antiestrogen but demonstrates a ten-fold greater potency as a protein kinase C (PKC) inhibitor compared to Tamoxifen. This compound also functions as a powerful regulator of ceramide metabolism in human Acute Myeloid Leukemia (AML) cells, by restricting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.

  • Potent protein kinase C (PKC) inhibitor.
  • Regulator of ceramide metabolism in human AML cells.
  • Inhibits glioma cell lines (T98G, U87, U138, U373, ALW, AUK, CAS cells).
  • Inhibits growth of MCF 7 human mammary carcinoma cells.
  • Major primary quantitative metabolite of tamoxifen.

Catalog No. 50-003-40956


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