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Sigma Aldrich N-Methylated Pomalidomide

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90-149-425MG 50 mg
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Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

N-Methylated pomalidomide is a ligand used as a negative control for pomalidomide (P0018) in the recruitment of the Cereblon (CRBN) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC™ Degraders for Targeted Protein DegradationHijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4Targeted Protein Degradation by Small MoleculesSmall-Molecule PROTACS: New Approaches to Protein DegradationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

CAS 2132978-44-8
Molecular Formula C20H23N3O8
Linear Formula C20H23N3O8
Quantity 50 mg
Synonym 3-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)propanoic acid; CrosslinkerE3 Ligase ligand conjugate; Protein degrader building block for PROTAC(R) research; Template for synthesis of targeted protein degrader
Molecular Weight (g/mol) 433.41 g/mol
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