N,N-Dimethylphosphoramidodichloridate, 97%, Thermo Scientific Chemicals

Description

N,N-Dimethylphosphoramidodichloridate is used in the synthesis of phosphoramidates as well as (RS)-ethyl N,N-dimethylphosphoramidocyanidate (Nerve agent GA) which is used as a chemical weapon. It forms active intermediates, which react with alcohols in situ to give esters. It is also used to convert primary alcohols to alkyl chlorides. Furthe, it serves as an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. In addition to this, it reacts with 1,2 diols to prepare cyclic phosphoric amides followed by alkenes after reduction.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
N,N-Dimethylphosphoramidodichloridate is used in the synthesis of phosphoramidates as well as (RS)-ethyl N,N-dimethylphosphoramidocyanidate (Nerve agent GA) which is used as a chemical weapon. It forms active intermediates, which react with alcohols in situ to give esters. It is also used to convert primary alcohols to alkyl chlorides. Furthe, it serves as an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. In addition to this, it reacts with 1,2 diols to prepare cyclic phosphoric amides followed by alkenes after reduction.

Solubility
Miscible with dimethoxyethane.

Notes
Moisture and air sensitive. Hygroscopic. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 677-43-0
• Molecular Formula: C2H6Cl2NOP
• Molecular Weight (g/mol): 161.95
• MDL Number: MFCD00013896
• InChI Key: YNHXBEVSSILHPI-UHFFFAOYSA-N
• Synonym: dimethylphosphoramidic dichloride, n,n-dimethylphosphoramidodichloridate, dichlorophosphoric dimethylamide, phosphoramidic dichloride, dimethyl, dimethylamido phosphoric dichloride, dimethylamidophosphoric acid dichloride, dimethylaminophosphoryl dichloride, n,n-dimethylphosphoramidic dichloride, dimethylamidophosphoric dichloride, n,n-dimethylphosphoramic dichloride
• PubChem CID: 12673
• IUPAC Name: N-dichlorophosphoryl-N-methylmethanamine
• SMILES: CN(C)P(=O)(Cl)Cl

• Density: 1.36
• Boiling Point: 89°C to 90°C (20 mmHg)
• Flash Point: >110°C (230°F)
• Refractive Index: 1.463
• Quantity: 25 g
• UN Number: UN3265
• Beilstein: 969956
• Sensitivity: Moisture sensitive
• Solubility Information: Miscible with dimethoxyethane.
• Formula Weight: 161.96
• Percent Purity: 97%
• Chemical Name or Material: N,N-Dimethylphosphoramidodichloridate

Safety and Handling

Hazard Category	H314-H335
Hazard Statement	GHS H Statement H314-H318 Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statement	P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
DOTInformation	Transport Hazard Class: 8; Packing Group: II; Proper Shipping Name: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S.
EINECSNumber	211-641-2
RTECSNumber	TB4025000
TSCA	No
Recommended Storage	Keep cold; Store under Nitrogen

SDS

RUO – Research Use Only