Medchemexpress LLC N,N'-Dinitrosopiperazine | 140-79-4 | 99.9% | 144.13 | 50 MG

Supplier:  Medchemexpress LLC HY13643350MG

N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) is identified as a carcinogen that specifically targets the nasopharyngeal epithelium and contributes to nasopharyngeal carcinoma (NPC) metastasis. It influences various signaling pathways through protein phosphorylation, including LYRIC at serine 568.

• Does not inhibit 6-10B cells at lower concentrations (0-8 μm)
• Exhibits cytotoxicity from 10 μm upwards
• Enhances 6-10B cell invasion and motility in a dose-dependent manner (2-8 μm)
• Increases cell invasion by 421.7% and motility by 328.2% at 6 μm
• Upregulates phospho-LYRIC s568 and LYRIC expression in CNE1 cells
• Inhibits cell motility and invasion in vivo at 40 mg/kg
• Facilitates NPC metastasis in vivo at 40 mg/kg
• Shows higher phospho-LYRIC expression in metastatic tumors in DNP-treated mice

Catalog No. 50-003-50544