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Medchemexpress LLC N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) | 2112732-01-9 | 519.58 | 100 MG
Supplier: Medchemexpress LLC HY140095100MG
N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs themselves contain two distinct ligands linked together, one targeting an E3 ubiquitin ligase and the other the protein of interest, utilizing the intracellular ubiquitin-proteasome system for selective target protein degradation. This product is for research use only.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Contains an alkyne group
- Capable of copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Reacts with azide-containing molecules
- Exploits ubiquitin-proteasome system
- Selectively degrades target proteins
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