AdipoGen N1-Guanyl-1 7-diaminoheptane

Supplier:  AdipoGen AGCR13702M010

Chemical. CAS 150417-90-6 parent 150333-69-0. Formula C8H22N4O4S. MW 270. Cell permeable competitive deoxyhypusine synthase DHPS inhibitor. Targets the spermidine-binding site of deoxyhypusine synthase Ki = 9.7 nM, and prevents the first step in the post-translational conversion of a single lysine to hypusine on eukaryotic initiation factor 5A eIF5A. The modification is essential for sustained cell growth and therefore eIF5A hypusination controls cell proliferation and has been linked to cancer. Hypusination of eIF-5aA in macrophages is required for the TCA/OXPHOS pathways by regulating the expression of the important enzymes of the pathways. GC7 blocks the expression of the key enzymes at the level of translation and blocks OXPHOS in macrophages. Useful tool for immunometabolism research. The polyamine spermidine as a substrate to generate hypusinated eIF5A. Elevated levels of polyamines are a hallmark of most tumor types.

Catalog No. 50-256-2199