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Medchemexpress LLC N2-(1H-Indol-5-yl)-6-(pyridin-4-yl)pyrazine-2,3-diamine acetate | 98.4% | 362.39 | 25 MG
Supplier: Medchemexpress LLC 25MGHY118304B
AKN-028 acetate is a novel tyrosine kinase (TK) inhibitor and a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. It inhibits FLT3 autophosphorylation, induces a dose-dependent cytotoxic response (mean IC50=1 μM), and induces apoptosis by activation of caspase 3. AKN-028 acetate can be used in research of acute myeloid leukemia (AML).
- Potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 of 6 nM.
- Inhibits FLT3 autophosphorylation.
- Induces dose-dependent cytotoxic response (mean IC50=1 μM).
- Induces apoptosis by activation of caspase 3.
- Inhibits growth of primary AML and MV4-11 cells in mice.
- Useful in research of acute myeloid leukemia (AML).
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