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Cayman Chemical N2-Isobutyryl GunosIn 25g

Supplier: Cayman Chemical 4028325 G

A STING agonist binds to wild-type STING (IC50 1.15 UM) as well as the STING R232H AQ and Q variants (IC50s 1.06 0.61 and 1.12 UM respectively) induces reporter gene expression in THP-1 and RAW 264.7 cells (EC50s 0.38 and 12.94 UM respectively) induces IFNB1 CXCL10 and IL6 mRNA expression in THP-1 cells at 5 UM increases plasma IFN-B levels and reduces tumor volume and the number of lung metastases in a B16/F10 murine melanoma model at 10 mg/kg
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