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Medchemexpress LLC N2,N2-Dimethylguanosine | 2140-67-2 | 311.29 | 25 MG
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Supplier:  Medchemexpress LLC 25MGHY113137

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N2,N2-Dimethylguanosine is a methylated nucleoside found in RNA and serves as a structural modification component of tRNA. It obstructs reverse transcriptase-mediated cDNA synthesis and is a crucial modification impacting sequencing efficiency in high-throughput RNA sequencing. This compound can selectively remove one of its methyl groups via AlkB mutant enzymes (such as D135S/L118V), converting it into N2-methylguanosine, which subsequently reduces hindrance to reverse transcription.

  • Found in RNA
  • Structural modification component of tRNA
  • Obstructs reverse transcriptase-mediated cDNA synthesis
  • Impacts sequencing efficiency in high-throughput RNA sequencing
  • Can be converted to N2-methylguanosine via AlkB mutant enzymes

Catalog No. 50-004-39994


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