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Medchemexpress LLC N2,N2-Dimethylguanosine | 2140-67-2 | 99.4% | 311.29 | 10 MG
SDP

Catalog No. 5000437199
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N2,N2-Dimethylguanosine is a methylated nucleoside found in RNA and is a structural modification component of tRNA. It hinders reverse transcriptase-mediated cDNA synthesis and is a key modification affecting sequencing efficiency in high-throughput RNA sequencing. It can selectively remove one methyl group through AlkB mutant enzymes (e.g., D135S/L118V) to convert into N2-methylguanosine, which reduces hindrance to reverse transcription.

  • Methylated nucleoside present in RNA and tRNA.
  • Hinders reverse transcriptase-mediated cDNA synthesis.
  • Key modification affecting sequencing efficiency in high-throughput RNA sequencing.
  • Can be selectively demethylated by AlkB mutant enzymes to N2-methylguanosine, reducing reverse transcription hindrance.
  • For research use only.

Catalog No. 50-004-37199 Supplier Medchemexpress LLC Supplier No. HY11313710MG
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N2,N2-Dimethylguanosine is a methylated nucleoside found in RNA and is a structural modification component of tRNA. It hinders reverse transcriptase-mediated cDNA synthesis and is a key modification affecting sequencing efficiency in high-throughput RNA sequencing. It can selectively remove one methyl group through AlkB mutant enzymes (e.g., D135S/L118V) to convert into N2-methylguanosine, which reduces hindrance to reverse transcription.

  • Methylated nucleoside present in RNA and tRNA.
  • Hinders reverse transcriptase-mediated cDNA synthesis.
  • Key modification affecting sequencing efficiency in high-throughput RNA sequencing.
  • Can be selectively demethylated by AlkB mutant enzymes to N2-methylguanosine, reducing reverse transcription hindrance.
  • For research use only.

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