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Medchemexpress LLC N2,N2-Dimethylguanosine | 2140-67-2 | 99.4% | 311.29 | 50 MG
Supplier: Medchemexpress LLC HY11313750MG
N2,N2-Dimethylguanosine is a methylated nucleoside present in RNA and a structural modification component of tRNA. It hinders reverse transcriptase-mediated cDNA synthesis and is a key modification affecting sequencing efficiency in high-throughput RNA sequencing. It can be selectively demethylated into N2-methylguanosine by AlkB mutant enzymes (such as D135S/L118V), reducing hindrance to reverse transcription.
- Methylated nucleoside present in RNA and a structural modification component of tRNA.
- Hinders reverse transcriptase-mediated cDNA synthesis.
- Key modification affecting sequencing efficiency in high-throughput RNA sequencing.
- Can be converted to N2-methylguanosine by AlkB mutant enzymes to reduce hindrance to reverse transcription.
- Appears as a white to off-white solid.
- Initial source: Endogenous metabolite.
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