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Medchemexpress LLC N2,N6,N6,5,7-pentamethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine-2,6-diamine | 1220646-23-0 | 99.3% | 359.45 g/mol | C17H21N5O2S | 50 MG
SDP

Supplier:  Medchemexpress LLC HY10192450MG

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AVN-492 is a highly selective antagonist of the 5-HT6 receptor used as a research compound to probe serotonergic mechanisms relevant to cognition and neurodegeneration. It exhibits picomolar affinity (Ki = 91 pM) and demonstrates favorable in vitro and in vivo ADME properties including brain penetration in preclinical models.

  • High potency: Ki = 91 pM at 5-HT6 receptor.
  • High selectivity for 5-HT6 over other serotonin receptors.
  • Typical purity 99.3% for reliable experimental performance.
  • Soluble in DMSO (50 mg/mL) and compatible with in vivo formulations.
  • Powder stability: -20°C storage for extended shelf life.
  • Supplied in small research quantities suitable for preclinical studies.

Catalog No. 50-002-48491


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