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Medchemexpress LLC N3-peg3-vc-pab-mmae | 99.1% | 1352.66 | C67H109N13O16 | 100 MG
Supplier: Medchemexpress LLC HY100874100MG
N3-PEG3-vc-PAB-MMAE is an azide-functional drug-linker conjugate for antibody-drug conjugate (ADC) development, combining a PEG3 spacer, a valine-citrulline (vc) cleavable dipeptide linked to a para-aminobenzyl (PAB) self-immolative spacer, and the cytotoxic payload monomethyl auristatin E (MMAE). The compound supports bioconjugation via copper-catalyzed or strain-promoted azide-alkyne cycloaddition for linker optimization and ADC synthesis.
- Azide handle enables copper-catalyzed and strain-promoted azide-alkyne cycloaddition for bioconjugation.
- PEG3 spacer increases hydrophilicity and flexibility.
- vc-PAB cleavable linker allows intracellular release of the payload.
- Contains monomethyl auristatin E (MMAE), a potent tubulin inhibitor payload.
- High reported purity suitable for ADC synthesis and analytical work.
- Supplied in multiple pack sizes for research-scale applications.
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