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Cayman Chemical N6-benzoyl-2-DeoxyadenosIn 1g
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Supplier:  Cayman Chemical 302621 G

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An agonist of mGluRs (EC50s 15 2 40 23 and 82 UM for mGluR1 -2 -3 -5 and -6 respectively in CHO cells expressing recombinant receptors and 800 UM for mGluR4 in baby hamster kidney cells) increases cAMP accumulation in adult rat cerebral cortex slices (EC50 47 8 UM) but not in isolated rat embryonic neurons or neonatal glial cells at 1-1000 UM increases phosphoinositide hydrolysis in neonatal rat cerebral cortex and hippocampal slices at 10-1000 UM induces convulsions in neonatal rats (ED50 100 mg/kg) an effect that can be reversed by administration of the NMDA receptor antagonists LY233053 and LY274614

Catalog No. 50-298-8183


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