Cayman Chemical Nacetyl Sulfamethoxazole 100mg

Supplier:  Cayman Chemical 17247100 MG

An inhibitor of MEK1 and -2 inhibits B-RAF- and C-RAF-induced phosphorylation of MEK1 (IC50s 3.4 and 1.8 nM respectively) and MEK2 (IC50s 1.6 and 0.92 nM respectively) inhibits the growth of two human colorectal cancer cell lines expressing mutant B-RAF (IC50s 0.48 and 0.52 nM) and seven cell lines expressing mutant K-Ras (IC50s 2.2-174 nM) but does not inhibit the growth of wild-type COLO 320DM cells expressing both B-RAF and K-Ras (IC50 10000 nM) reduces tumor growth in HT-29 and COLO 205 mouse xenograft models at 0.3 and 1 mg/kg per day decreases M. tuberculosis-induced increases in hind paw volume in a rat model of arthritis at 0.03 and 0.1 mg/kg per day

Catalog No. 50-296-6320