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AdipoGen NADE M tuberculosis His
Supplier: AdipoGen AG40T0108C050
Protein. NAD synthetase Mycobacterium tuberculosis with mutation S444A is fused at the N-terminus to a His-tag. Source E. coli. Endotoxin content N/A. Liquid. In 20mM TRIS-HCl, pH 7.8. Purity >98% SDS-PAGE. NAD synthetase is an essential enzyme involved in both the de novo biosynthesis and salvage of NAD, catalyzing the final step of both pathways. Since NAD has a vital role in cell metabolism, the enzyme represents a valid target for the development of new antimycobacterial agents. It can use both glutamine or ammonia as a nitrogen source. Catalytic activity ATP deamido-NAD L-glutamine H2O = AMP diphosphate NAD L-glutamate
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