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AdipoGen Nafamostat . mesylate (10 mg)
SDP

Supplier:  AdipoGen AGCR13731M010

Encompass_Preferred

Chemical. CAS: 82956-11-4. Formula: C19H17N5O2 . 2CH4O3S. MW: 347.4 . 192.2. Nafamostat mesylate is a cell permeable broad spectrum potent and reversible synthetic serine protease inhibitor and kallikrein inhibitor in vitro and in vivo. It inhibits trypsin (Ki=15nM), tryptase (Ki=95.3pM) and additional proteases in the coagulation cascade including thrombin (Ki=0.84µM). Nafamostat mesylate is a short-acting anticoagulant with anti-inflammatory, anticancer and antiviral properties. Nafamostat mesylate inhibits TMPRSS2-dependent host cell entry of MERS-CoV. It is also an inhibitor of the enzyme transmembrane serine protease TMPRSS2 and blocks the entry of SARS-CoV-2 (COVID-19) into lung cells in vitro, with roughly 15-fold higher efficiency than Camostat mesylate (Prod. No. AG-CR1-3716), with an EC50 in the low nanomolar range.

Catalog No. 50-205-4145


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