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Cayman Chemical nagrelIdehydrochlorIde 10mg
Supplier: Cayman Chemical 2141110 MG
A PDE3 inhibitor (IC50 = 36 nM for the human platelet enzyme); inhibits thrombopoietin-induced megakaryocytopoiesis of isolated human CD34+ progenitor cells (IC50 = 26 nM); reduces ADP-, collagen-, thrombin-, or arachidonic acid-induced platelet aggregation in isolated rabbit platelet rich-plasma (EC50s = 0.31, 0.08, 0.18, and 0.1 UG/ml, respectively); inhibits platelet thrombus formation in a dog model of electrically induced carotid artery thrombosis when administered at 0.5-5 mg/kg
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