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AdipoGen NAI-107
SDP

Supplier:  AdipoGen AGCN20307M001

Encompass_Preferred

Chemical. CAS 845293-74-5. Formula C94H127ClN26O27S5 A1, C94H127ClN26O26S5 A2. MW 2249.0 A1 R=OH2233.0 A2 R=H. Isolated from Microbispora sp. Antibacterial class I lantibiotic. Mixture of two similarly active and structurally related polypeptides A1, 2246Da and A2, 2230Da of 24 amino acids linked by 5 intramolecular thioether bridges. Inhibits cell wall synthesis and consequently bacterial growth by forming a complex with lipid intermediate II Lipid II, a key intermediate in peptidoglycan biosynthesis. Efficiently interfers with late stages of cell wall biosynthesis leading to accumulation of the soluble peptidoglycan precursor UDP-N-acetylmuramic acid-pentapeptide UDP-MurNAc-pentapeptide in the cytoplasm. Active against aerobic and anaerobic Gram-positive pathogens, including all antibiotic-resistant strains e.g. MRSA and VRE in whole cell and in vitro assays as well as in vivo.

Catalog No. 50-256-2621


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