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AdipoGen NAI-802
Supplier: AdipoGen AGCN20310M001
Chemical. CAS 1426209-02-0. Formula C90H141N25O26S4. MW 2117.5. Isolated from Actinoplanes sp. Actagardin-related class II lantibiotic. Antibacterial with improved activity than actagardine against Staphylococcus spp. and Streptococcus spp. Shows significant activity against Gram-positive anaerobic bacteria, such as Clost. difficile, Clostridium butyricum, Clostridium perfringens and Peptostreptococcus asaccharolyticus. Most probably inhibits cell wall synthesis and consequently bacterial growth by forming a complex with lipid intermediate II Lipid II, a key intermediate in peptidoglycan biosynthesis. Potential novel antimicrobial agent for the treatment of infections caused by Gram-positive pathogens including resistant strains.
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