Nalidixic acid, 99.5%

Description

Nalixidic acid, or nalixidin, CAS # 389-08-2, is a quinolone antibiotic used to inhibit DNA gyrase and prevent cell division. | CAS: 389-08-2 | C₁₂H₁₂N₂O₃ | 232.24 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Nalixidic acid is a synthetic quinolone that is a monocarboxylic acid composed of 1,8-naphthyridine substituted with carboxylic acid, ethyl, and methyl groups

• Nalixidic acid is a DNA gyrase inhibitor that prevents DNA synthesis and subsequent cell divisions

Applications

• Nalixidic acid is primarily effective against gram-negative bacteria

• It may be useful for bacterial resistance studies and laboratory research on drug allergies and cross-reactivity

• Nalixidic acid is suitable for high-performance liquid chromatography (HPLC) and related biochemistry laboratory applications

Specifications

Chemical Identifiers

• CAS: 389-08-2
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight (g/mol): 232.24
• MDL Number: MFCD00006884
• InChI Key: MHWLWQUZZRMNGJ-UHFFFAOYSA-N
• Synonym: nalidixic acid, nalidixin, nevigramon, nalidixate, uronidix, innoxalon, nalidixan, nalitucsan, sicmylon, unaserus
• PubChem CID: 4421
• ChEBI: CHEBI:100147
• IUPAC Name: 1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
• SMILES: CCN1C=C(C(=O)C2=C1N=C(C=C2)C)C(=O)O

• CAS Min %: 99.4
• CAS Max %: 100.0
• Melting Point: 225.0°C to 231.0°C
• Color: White to Yellow
• Infrared Spectrum: Authentic
• Assay Percent Range: 99.5%
• Packaging: Glass bottle
• Quantity: 5 g
• Beilstein: 25, V,7, 384
• Merck Index: 15, 6444
• Solubility Information: Solubility in water: 0.1g/L (23°C). Other solubilities: soluble in alkali solutions,35mg/mL chloroform- 1.6mg/mL toluene (23°C),1.3mg/mL methanol- 0.9mg/mL ethanol (23°C),0.1mg/mL ether (23°C)
• Formula Weight: 232.24
• Percent Purity: 99.5%
• Physical Form: Powder
• Chemical Name or Material: Nalidixic acid, 99.5%

Safety and Handling

Hazard Category	GHS Signal Word: Danger
Hazard Statement	GHS H Statement May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary Statement	GHS P Statement Avoid breathing dust/fume/gas/mist/vapors/spray. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Wear eye protection/face protection.
EINECSNumber	206-864-7
RTECSNumber	QN2885000

SDS

RUO – Research Use Only