Naloxone Hydrocloride, MP Biomedicals™

Description

Naloxone Hydrocloride Off-white Crystalline Powder

• The role of naloxone (1μM) and other opioids on apoptosis in several human cancer cell lines has been probed. Naloxone (10-100μM) has been used to study proliferation and neurogenesis in cultured rat adult hippocampal progenitors.
• Naloxone has also been utilized to modulate the NMDA receptor activation capability of theμ-opioid receptor agonist DAMGO. It displaces morphine and other opiate agonists from the opiate receptor.
• It is more potent than Nalorphine and is also an effective antagonist for mixed agonist-antagonist drugs such as pentazorcine. Naloxone has no respiratory depressant activity.

Specifications

Chemical Identifiers

• CAS: 357-08-4
• Molecular Formula: C19H22ClNO4
• Molecular Weight (g/mol): 363.84
• InChI Key: RGPDIGOSVORSAK-STHHAXOLSA-N
• Synonym: Narcan, EN-1530, (5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride, 17-allyl-4,5α- epoxy-3,14-dihydroxymorphinan-6-one hydrochloride

• Melting Point: 129.0°C to 129.2°C (literature)
• Color: Off-white
• Quantity: 25 mg
• Solubility Information: Soluble in water (50mg/mL - clear, colorless to faint yellow solution), ethanol (3.3mg/mL), or methanol (50mg/mL - clear, colorless solution).
• Physical Form: Crystalline Powder

Safety and Handling

RTECSNumber	QD2275000
storageNote1	Store at +4°C, Store Desiccated.