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Medchemexpress LLC NAMI-A | 201653-76-1 | 98.0% | 458.18 | 1 ML
Supplier: Medchemexpress LLC HY1937610MM/1ML
NAMI-A is a ruthenium-based drug characterized by its selective activity against tumor metastases, and it inhibits adhesion and migration.
- Significantly affects tumor cells with metastatic ability.
- Half-life of elimination from the lungs is longer than for the liver, kidney, and primary tumor.
- Active on tumor cells when bound to collagen, as shown by an in vitro invasion test.
- Inhibits matrix metalloproteinases MMP-2 and MMP-9 at micromolar concentrations.
- Inhibits the adhesion and migration of colorectal cancer cells.
- Decreases α5β1 integrin expression and FAK auto-phosphorylation on Tyr 397.
- Reference dose for in vivo studies is 35 mg/kg/day.
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