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Medchemexpress LLC Nampt-IN-5 | 2380013-17-0 | >98.0% | 50 MG
Supplier: Medchemexpress LLC HY13060650MG
Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor that also inhibits CYP3A4 activity. It exhibits cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23 cell lines, respectively, demonstrating antiproliferative effects. In vivo, it causes significant body weight loss in nude mice and shows favorable ADME data.
- Potent NAMPT inhibitor
- Inhibits CYP3A4 activity
- Exhibits antiproliferative activity against A2780 and COR-L23 cell lines
- Shows good ADME data in vitro
- Induces significant body weight loss in nude mice in vivo
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