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Apexbio Technology LLC Naphthoquine phosphate 173531-58-3 5mg
Supplier: Apexbio Technology LLC A36415
Naphthoquine phosphate (CAS 173531-58-3) is an antimalarial agent targeting multiple isolates of Plasmodium falciparum In in vitro studies naphthoquine phosphate demonstrates inhibitory activity with IC50 values ranging from approximately 0 1 to 5 2 nM Enhanced efficacy was observed in animal models infected with Plasmodium knowlesi when naphthoquine phosphate was administered in combination with artemisinin In clinical trials involving adult patients with uncomplicated P falciparum malaria an oral single-dose regimen of naphthoquine phosphate and artemisinin led to parasite clearance within an average of 34 6 14 3 hours Based on these pharmacological properties naphthoquine phosphate holds research potential in antimalarial drug resistance and combination therapy strategies
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