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Medchemexpress LLC Naproxen etemesil | 385800-16-8 | 99.89% | 336.40 | 50 MG
Supplier: Medchemexpress LLC HY1967550MG
Naproxen etemesil is a lipophilic, non-acidic, inactive proagent of naproxen that is hydrolyzed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively, in cell assay. It is for research use only.
- Lipophilic, non-acidic, inactive prodrug of naproxen
- Hydrolyzed to pharmacologically active Naproxen upon absorption
- Inhibits COX-1 and COX-2 with IC50s of 8.72 μM and 5.15 μM, respectively, in cell assay
- Exerts anti-inflammatory and antifibrotic effects in a mouse model of bleomycin-induced lung fibrosis
- Downregulates TGF-β levels and Smad3/4 complex formation
- Inhibits inflammatory pain, fever, and PGE2 synthesis
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