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Apexbio Technology LLC Naproxen Sodium 26159-34-2 10g
Supplier: Apexbio Technology LLC B598410000
Naproxen sodium (CAS 26159-34-2) is a non-selective cyclooxygenase (COX) inhibitor that suppresses both COX-1 and COX-2 activity In vitro it exhibits IC50 values of 35 48 mol/L for COX-1 and 64 62 mol/L for COX-2 Naproxen sodium influences satellite cell biology by affecting proliferation fusion and differentiation particularly when both COX-1 and COX-2 are inhibited In HCA-7 colon cancer cells naproxen reduces cell viability with an IC50 of 1 45 0 07 M after 48-hour exposure Clinically repeated dosing in volunteers results in substantial inhibition of COX isoforms while research in menstrual migraine models shows significant reductions in headache parameters
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