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Medchemexpress LLC Naratriptan hydrochloride | 143388-64-1 | 99.7% | 5 MG
Supplier: Medchemexpress LLC HYB0197A5MG
Naratriptan hydrochloride (GR-85548A) is a selective 5-HT1B/1D receptor agonist. It is peripherally active and exhibits good oral bioavailability, causing cranial artery vasoconstriction by activating 5-HT1B/1D receptors. It also suppresses trigeminal nerve-mediated dural neurogenic plasma extravasation and reduces sterile inflammation. It is primarily used in acute migraine research, targeting cranial vascular and neuroinflammatory mechanisms.
- Selective 5-HT1B/1D receptor agonist
- Peripherally active with good oral bioavailability
- Causes cranial artery vasoconstriction
- Suppresses trigeminal nerve-mediated dural neurogenic plasma extravasation
- Reduces sterile inflammation
- Targets human recombinant 5-HT1B and 5-HT1D receptors
- Inhibits plasma protein extravasation in rat dural neurogenic inflammation model
- High oral bioavailability in rats and dogs
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