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Cayman Chemical NaratrIptnhydrochlorIde 10mg
Supplier: Cayman Chemical 2375410 MG
A potent 5-HT1B and 5-HT1D receptor agonist (IC50s = 9.4 and 1.5 nM, respectively, in a radioligand binding assay using human recombinant receptors); selective for 5-HT1B and 5-HT1D, lacking activity in rat aorta, guinea pig colon, and pig vena cava that highly express 5-HT2A, 5-HT4, and 5-HT7 receptors, respectively, at concentrations up to 10 μM; induces contraction of isolated human coronary arteries (EC50 = 170 nM); induces dose-dependent vasoconstriction of the carotid vascular bed in dogs when administered at doses ranging from 1-300 μg/kg; inhibits plasma protein extravasation induced by electrical stimulation of the trigeminal ganglion in the dura of anesthetized rats
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