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Medchemexpress LLC Navlimetostat hydrochloride | 99.6% | 501.34 | 25 MG
Supplier: Medchemexpress LLC 25MGHY139611C
Navlimetostat hydrochloride is a potent, orally active, and selective PRMT5-MTA complex inhibitor. It exhibits antineoplastic activity both in vitro and in vivo, making it a valuable compound for cancer studies.
- Potent, orally active, selective inhibitor of the PRMT5-MTA complex
- IC50s are 3.6 nM for PRMT5-MTA and 20.5 nM for PRMT5
- Binds to the PRMT5-MTA complex with a KD value of 0.14 pM
- Demonstrates antineoplastic activity in both in vitro and in vivo models
- Used in research for cancer studies
- Inhibits PRMT5 activity in MTAP-deleted HCT116 cells
- Inhibits cell viability in MTAP del HCT116 cells
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