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Apexbio Technology LLC NB-598 131060-14-5 10mg
Supplier: Apexbio Technology LLC A364510
NB-598 is a selective inhibitor targeting squalene epoxidase (SE) an enzyme that catalyzes the conversion of squalene into 2 3-oxidosqualene a crucial intermediate step within the cholesterol biosynthesis pathway Through competitive inhibition of SE NB-598 interferes with the metabolic pathway associated with triglyceride synthesis involving downstream intermediates such as farnesol In experimental studies utilizing isolated murine pancreatic islets NB-598 inhibits insulin secretion under basal and glucose-stimulated conditions suggesting a functional relationship between SE activity and insulin release processes Additionally NB-598 exerts inhibitory effects on voltage-dependent calcium channels (CaV channels) pointing to a potential link between SE-mediated lipid metabolism and calcium-related cellular signaling in endocrine research This compound serves as a pharmacological tool in lipid metabolism diabetes and endocrine function studies
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