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Medchemexpress LLC NB-598 | 131060-14-5 | 98.7% | 449.67 | 5 MG
Supplier: Medchemexpress LLC HY163435MG
NB-598 is a potent and competitive inhibitor of squalene epoxidase (SE) and suppresses triglyceride biosynthesis through the farnesol pathway. It is also a click chemistry reagent containing an Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that have Azide groups.
- Potent and competitive squalene epoxidase inhibitor.
- Suppresses triglyceride biosynthesis.
- Functions as a click chemistry reagent.
- Designed for research use only.
- Inhibits cholesterol biosynthesis in HepG2 cells with an IC50 of 0.02 μM.
- Reduces total cholesterol level in MIN6 cells by 36±7% at 10 μM.
- Decreases cholesterol from PM, ER, and SG by approximately 49%, 46%, and 48% respectively.
- Dose-dependently inhibits insulin secretion.
- Reduces ACAT activity.
- Suppresses the secretion of cholesterol and triacylglycerol from HepG2 cells.
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