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Apexbio Technology LLC NB-598 hydrochloride(Synonyms: NB-598 HCl, NB-598 hydrochloride, NB598 hydrochloride, NB598 HCl, NB598), 5mg, CAS: 136719-25-0.
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Supplier:  Apexbio Technology LLC A36465

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NB-598 hydrochloride (CAS 136719-25-0) is a benzylamine derivative that selectively inhibits squalene epoxidase (SQLE) a crucial enzyme in cholesterol biosynthesis Acting as a competitive inhibitor NB-598 interferes with SQLE-catalyzed conversion of squalene displaying IC50 values of 4 4 nM and 0 75 nM in cell-free and HepG2 microsomal assays respectively In HepG2 cells NB-598 inhibits cholesterol synthesis (IC50 3 4 nM) without affecting triglycerides phospholipids or fatty acids In vivo it reduces serum cholesterol in rodents and dogs by upregulating LDL receptor activity Thus NB-598 serves as a valuable compound in hypercholesterolemia and atherosclerosis research

Catalog No. 50-000-60314


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