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Apexbio Technology LLC NB-598 Maleate 155294-62-5 10mg
Supplier: Apexbio Technology LLC A364710
NB-598 Maleate is a small-molecule inhibitor targeting squalene epoxidase (SE) an essential enzyme in cholesterol biosynthesis It is designed to inhibit SE thereby disrupting the oxygenation of squalene and affecting downstream synthesis of cholesterol intermediates particularly within farnesol-dependent pathways leading to triglyceride biosynthesis NB-598 Maleate exerts its biological activity primarily through inhibition of squalene epoxidase In mouse pancreatic islet models NB-598 Maleate reduces insulin secretion under both basal and glucose-stimulated conditions Additionally this compound inhibits calcium voltage-dependent (CaV) ion channels in cellular assays Based on these pharmacological properties NB-598 Maleate holds research potential in studying cholesterol biosynthesis pathways lipid metabolism insulin regulation and the physiological role of CaV channels
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