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Medchemexpress LLC NBD-14189 | 2234273-72-2 | 99.8% | 428.40 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY139985

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NBD-14189 is a potent HIV-1 entry antagonist that binds to HIV-1 gp120, exhibiting potent antiviral activity. It demonstrates anti-HIV-1 activity and cytotoxicity in both single-cycle (TZM-bl cells) and multi-cycle (MT-2 cells) assays, and prevents HIV-1 mediated cell-cell fusion.

  • Potent HIV-1 entry antagonist (IC50 of 89 nM against HIV-1HXB2 pseudovirus)
  • Binds to HIV-1 gp120
  • Potent antiviral activity (EC50<200 nM)
  • Anti-HIV-1 activity (IC50=0.089 μM) and cytotoxicity (CC50=21.9 μM) in single-cycle assays
  • Anti-HIV-1 activity (IC50=0.18 μM) and cytotoxicity (CC50=22.1 μM) in multi-cycle assays
  • Prevents HIV-1 mediated cell-cell fusion (IC50=9.4 μM)
  • Weak or no inhibition of hERG current (IC50=3.0 μM)

Catalog No. 50-003-50137


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