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Medchemexpress LLC NBI-31772 | 374620-70-9 | 98.9% | 341.27 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY11013550MG

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NBI-31772 is a non-selective IGFBP inhibitor with a Ki of 47 nM. It exhibits neuroprotective effects, reducing infarct volume during cerebral ischemia. It can also restore or enhance proteoglycan synthesis in osteoarticular chondrocytes and increases the effect of IGF3 on zebrafish oocyte maturation.

  • Stimulates the synthesis of IGF-1-dependent proteoglycans in human OA chondrocytes.
  • Significantly stimulates the percentage of rabbit articular chondrocyte-associated proteoglycans.
  • Dose-dependently induces the maturation of zebrafish oocytes.
  • Reduces total infarct volume and cortical infarct volume in rats with middle cerebral artery occlusion (MCAO) model.
  • Reduces cortical infarct size and brain swelling in rats with intraluminal suture MCAO model.
  • Induces germinal vesicle rupture in zebrafish.

Catalog No. 50-003-43629


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