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Cayman Chemical NCGC00244536 10mg

Supplier: Cayman Chemical 1847810 MG
A KDM4B/JMJD2B inhibitor (IC50 = ~10 nM); selective for KDM4B/JMJD2B over KDM5A/JARID1 and LSD1 but does inhibit KDM4A/JMJD2A, KDM4C/JMJD2C, and KDM4D/JMJD2D at 10 μM; inhibits the growth of various prostate cancer cells (IC50s = <1 μM for all); reduces androgen receptor levels and H3K9 trimethylation in isolated human solid prostate tumors; reduces tumor volume in a PC3 mouse xenograft model at 20 mg/kg
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